# PeptidesDB

> Open-source, citation-dense, side-by-side comparable peptide research reference. Every claim links to a peer-reviewed source. MIT-licensed code and content.

## Project

- Site: https://peptidesdb.org
- Repository: https://github.com/peptidesdb/peptidesdb
- License: MIT
- API: https://peptidesdb.org/api/peptides

## Peptides

- [5-Amino-1MQ](https://peptidesdb.org/p/5-amino-1mq): NNMT Inhibitor (small molecule). Selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in obesity that consumes SAM and NAD+. Inhibition restores cellular methylation and energy balance. Animal studies (Neelakantan 2018) sho
- [AOD-9604](https://peptidesdb.org/p/aod-9604): Lipolytic HGH C-terminal fragment. Modified 16-amino-acid C-terminal fragment of human growth hormone (residues 176-191) engineered to retain the lipolytic activity of native HGH while eliminating IGF-1 elevation, glucose-handling effects, and anti-insulin signaling. Acts vi
- [BPC-157](https://peptidesdb.org/p/bpc-157): Pentadecapeptide. Synthetic 15-amino-acid pentadecapeptide derived from a protective sequence found in human gastric juice (BPC = Body Protection Compound). Stable in simulated gastric conditions and the most extensively studied healing peptide in animal lit
- [CJC-1295 (no DAC)](https://peptidesdb.org/p/cjc-1295): GHRH Analogue (modified GRF 1-29). 29-amino-acid GHRH analogue based on the active N-terminal fragment of human GHRH (GRF 1-29) with four amino-acid substitutions for stability against enzymatic degradation. Unlike CJC-1295 with DAC (Drug Affinity Complex), the no-DAC varian
- [DSIP](https://peptidesdb.org/p/dsip): Nonapeptide. 9-amino-acid peptide first isolated from rabbit cerebral venous blood during electrically induced delta-wave sleep (Schoenenberger / Monnier, 1977). Modulates sleep-wake architecture, reduces stress response, and shows anxiolytic effects in
- [Epitalon](https://peptidesdb.org/p/epitalon): Tetrapeptide bioregulator. Synthetic tetrapeptide (Ala-Glu-Asp-Gly) developed at the Saint Petersburg Institute of Bioregulation and Gerontology as the active analog of epithalamin, a natural pineal extract. Khavinson et al. demonstrated telomerase-activating and tel
- [GHK-Cu](https://peptidesdb.org/p/ghk-cu): Copper-binding tripeptide. Endogenous copper-binding tripeptide (Gly-His-Lys) found in human plasma at ~200 ng/mL in young adults, declining sharply with age. Forms a 1:1 complex with Cu(II) to deliver copper to tissues, regulates collagen, elastin, and glycosaminogl
- [GHRP-2](https://peptidesdb.org/p/ghrp-2): GHRP / Ghrelin Receptor Agonist. Synthetic hexapeptide GHRP — D-Ala-D-2-Nal-Ala-Trp-D-Phe-Lys-NH₂. Stronger GH-stimulating action than Ipamorelin but with measurable cortisol and prolactin elevation at higher doses. Approved in Japan as a diagnostic agent (Pralmorelin) for
- [GHRP-6](https://peptidesdb.org/p/ghrp-6): GHRP / Ghrelin Receptor Agonist. Earlier-generation hexapeptide GHRP — His-D-Trp-Ala-Trp-D-Phe-Lys-NH₂. Among the first GHRPs characterised by the Bowers lab. Produces strong GH release plus pronounced appetite stimulation via ghrelin-receptor agonism. Largely superseded b
- [Hexarelin](https://peptidesdb.org/p/hexarelin): GHRP / Ghrelin Receptor Agonist. Synthetic hexapeptide GHRP that activates the ghrelin receptor (GHS-R1a) with high potency. Distinct from ipamorelin in producing a stronger GH pulse but with measurable cortisol + prolactin elevation at higher doses. Most-studied GHRP for 
- [Ipamorelin](https://peptidesdb.org/p/ipamorelin): GHRP / Ghrelin Receptor Agonist. Pentapeptide growth-hormone-releasing peptide (GHRP) that selectively activates the ghrelin receptor (GHS-R1a) on the anterior pituitary, eliciting GH release without the cortisol or prolactin elevation characteristic of earlier GHRPs. Orig
- [KPV](https://peptidesdb.org/p/kpv): Tripeptide (Lys-Pro-Val). Tripeptide (Lys-Pro-Val) corresponding to the C-terminus of α-melanocyte- stimulating hormone (α-MSH). Retains the anti-inflammatory and immune- modulatory properties of full α-MSH without the pigmentation effects. Multiple animal studies s
- [Liraglutide](https://peptidesdb.org/p/liraglutide): GLP-1 Receptor Agonist. Modified human GLP-1 with C-16 fatty-acid acylation enabling albumin binding and a ~13 hour half-life. FDA-approved 2010 (Victoza, type 2 diabetes) and 2014 (Saxenda, chronic weight management). The LEADER trial (Marso et al., NEJM 2016) de
- [Melanotan-II](https://peptidesdb.org/p/melanotan-2): α-MSH Analog (cyclic heptapeptide). Synthetic cyclic heptapeptide derived from α-MSH (Ac-Nle-Asp-His-D-Phe- Arg-Trp-Lys-OH cyclic). Activates multiple melanocortin receptors — MC1R drives skin pigmentation, MC4R drives sexual arousal pathways. Distinct from PT-141 / bremelano
- [MK-677](https://peptidesdb.org/p/mk-677): Ghrelin Receptor Agonist (oral). Non-peptide, orally bioavailable ghrelin receptor agonist. Distinct from injectable GHRPs because it is a small molecule (not technically a peptide, but listed for class completeness) with a long ~24 hour half-life. The Nass et al. 2008 tri
- [MOTS-c](https://peptidesdb.org/p/mots-c): Mitochondrial-derived peptide. 16-amino-acid mitochondrial-encoded peptide (mitokine) translated from the 12S rRNA short open reading frame. Activates AMPK via folate-cycle inhibition, increasing fatty acid oxidation, glucose tolerance, and mitochondrial biogenesis. Endo
- [Pinealon](https://peptidesdb.org/p/pinealon): Tetrapeptide bioregulator. Synthetic tetrapeptide (Glu-Asp-Arg) developed at the Saint Petersburg Institute of Bioregulation and Gerontology. Russian literature reports neuroprotective and antioxidant effects, particularly in age-related cognitive decline. Limited We
- [PT-141](https://peptidesdb.org/p/pt-141): Melanocortin-4 Receptor Agonist. Cyclic 7-amino-acid peptide and MC4R-selective agonist derived from α-MSH. FDA-approved 2019 (Vyleesi) for hypoactive sexual desire disorder in pre-menopausal women — the first centrally-acting peptide for sexual dysfunction. Acts on hypoth
- [Retatrutide](https://peptidesdb.org/p/retatrutide): GLP-1 / GIP / Glucagon Triple Agonist. Investigational triple-receptor agonist of GLP-1, GIP, and glucagon receptors developed by Eli Lilly. The Phase 2 trial (Jastreboff et al., NEJM 2023) demonstrated 24.2% body-weight reduction at 12 mg over 48 weeks — the largest weight-loss
- [Selank](https://peptidesdb.org/p/selank): Heptapeptide bioregulator. Synthetic 7-amino-acid peptide developed at the Russian Academy of Medical Sciences from the immunomodulator tuftsin. Demonstrates anxiolytic effects comparable to benzodiazepines but without sedation, cognitive impairment, or dependency. A
- [Semaglutide](https://peptidesdb.org/p/semaglutide): GLP-1 Receptor Agonist. Long-acting glucagon-like peptide-1 (GLP-1) receptor agonist with C-18 fatty-acid acylation that enables albumin binding and a ~7-day half-life. FDA-approved 2017 for type 2 diabetes (Ozempic) and 2021 for chronic weight management (Wegovy)
- [Semax](https://peptidesdb.org/p/semax): Heptapeptide ACTH(4-10) analog. Synthetic 7-amino-acid peptide derived from the active fragment of adrenocorticotropic hormone (ACTH 4-10). Developed at the Russian Academy of Sciences in the 1980s. Used clinically in Russia for stroke recovery and cognitive support. Incr
- [Sermorelin](https://peptidesdb.org/p/sermorelin): GHRH Analogue (1-29). 29-amino-acid synthetic analogue of the bioactive N-terminal fragment of human GHRH. Was FDA-approved (1990s) under the brand Geref for diagnosis of GH deficiency in children but withdrawn from the market for commercial reasons (not safety)
- [SS-31](https://peptidesdb.org/p/ss-31): Mitochondrial-targeted tetrapeptide. Synthetic four-amino-acid peptide that selectively localises to the inner mitochondrial membrane by binding cardiolipin. Stabilises cristae structure, preserves electron transport chain efficiency, and reduces ROS generation in stressed mit
- [TB-500](https://peptidesdb.org/p/tb-500): Actin-sequestering peptide. Synthetic 17-amino-acid fragment of human thymosin β4 (TMSB4X), itself a 43-residue actin-sequestering protein abundant in platelets, white blood cells, and many other tissues. Promotes endothelial cell migration, blood vessel development, 
- [Tesamorelin](https://peptidesdb.org/p/tesamorelin): GHRH Analogue. Synthetic 44-amino-acid GHRH analogue, FDA-approved (2010) for HIV-associated lipodystrophy. Stimulates pulsatile growth hormone release from the anterior pituitary, elevating IGF-1 and reducing visceral adipose tissue by 15–20% over 26 wee
- [Tesofensine](https://peptidesdb.org/p/tesofensine): Triple monoamine reuptake inhibitor (small molecule). Originally developed for Alzheimer's and Parkinson's, tesofensine is a small-molecule (not technically a peptide) triple reuptake inhibitor of serotonin, norepinephrine, and dopamine. Phase 2b in obesity (Astrup Lancet 2008) demonstrated 9.
- [Thymalin](https://peptidesdb.org/p/thymalin): Polypeptide complex (thymus-derived). Polypeptide complex isolated from calf thymus by the Khavinson group (Saint Petersburg Institute of Bioregulation and Gerontology). Used in Russia for decades to support immune function in elderly and post- treatment patients. Russian clini
- [Thymosin α-1](https://peptidesdb.org/p/thymosin-alpha-1): Synthetic 28-AA thymic peptide. Synthetic 28-amino-acid peptide identical to a peptide isolated from calf thymus. Approved as Zadaxin (thymalfasin) in 35+ countries for chronic hepatitis B + C, immune restoration after chemotherapy, and as an HIV/HBV vaccine adjuvant. Not
- [Tirzepatide](https://peptidesdb.org/p/tirzepatide): GIP / GLP-1 Dual Receptor Agonist. First-in-class dual agonist of glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1) receptors. FDA-approved 2022 for type 2 diabetes (Mounjaro) and 2023 for chronic weight management (Zepbound). The SURMOUN

## Comparison

Pairwise comparison views at /compare/<peptide-a>-vs-<peptide-b> for any two peptides above. Each page shows mechanism, dosage, evidence, side effects, administration, and stack synergies side-by-side.

## Disclaimer

PeptidesDB is a research and educational reference. It is NOT medical advice. Consult a licensed clinician before any decision affecting health.