Crystagen
also known as Lys-Glu-Asp-Gly, KEDG, Кристаген
Synthetic tetrapeptide (Lys-Glu-Asp-Gly) developed within the Khavinson bioregulator school. Animal studies demonstrate B-cell activation and immune modulation in aging spleen tissue. Mechanism involves B-lymphocyte stimulation without apparent enhancement of cellular proliferation. Used within Russian geroprotective research tradition for thymic-immune support.
- Class
- Tetrapeptide Bioregulator
- Evidence level
- Mechanistic animal evidence
- Regulatory status
- Not FDA-approved (US) — research use only
At a glance
SQ · Protocol variable
Primary target — B-lymphocytes in splenic tissue [hervyakova-2014].
Pathway — B-cell activation → Immune modulation during aging [hervyakova-2014].
Downstream effect — B-cell activation via apoptosis reduction; no observed increase in splenic cell renewal [hervyakova-2014].
Origin — Synthetic Lys-Glu-Asp-Gly tetrapeptide — Khavinson bioregulator series.
Feedback intact — Unknown — bioregulator mechanism not fully characterized.
| Parameter | Value |
|---|---|
| Standard dose | Not standardized — variable protocolsRussian bioregulator literature does not specify unified human dosing. |
| Evidence basis | Animal / mechanistic |
| Route | Subcutaneous (presumed from bioregulator class) |
| Frequency | Unknown — bioregulator protocols variable |
| Duration | Unknown — chronic administration presumed in animal models |
| Half-life | Not reported |
Reconstitution
A pure mass-to-volume utility. Enter what you have in the vial; the atlas computes the volume per dose. No prescription information.
Evidence base: Russian-language clinical literature, primarily from the St. Petersburg Institute of Bioregulation and Gerontology (Khavinson school), 1985 onward. Not extensively peer-reviewed in Western journals.
- — Active autoimmune disease (theoretical)
- — Pregnancy / lactation (no data)
- — Active B-cell malignancies
- 01Route
Subcutaneous injection — presumed from bioregulator class convention. Specific anatomical sites not standardized.
- 02Reconstitution
Protocol not standardized. If lyophilized, sterile water or bacteriostatic saline typical for peptide bioregulators.
- 03Timing
Not specified. Bioregulator protocols vary — some practitioners advocate evening dosing, others morning.
- 04Storage
Lyophilized: room temperature, light-protected. Reconstituted: refrigerate, use within days to weeks depending on preservative.
Frequently asked
How does Crystagen work?
Crystagen acts on B-lymphocytes in splenic tissue, signalling via B-cell activation → Immune modulation during aging. [hervyakova-2014][hervyakova-2014]
Is Crystagen FDA-approved?
Crystagen is not FDA-approved in the United States and is handled as a research compound (research use only). Regulatory status may differ in other jurisdictions.
Sources
of 40 rendered claims carry a resolvable citation.
- [hervyakova-2014]Сhervyakova 2014 — [Molecular aspects of immunoprotective activity of peptides in spleen during the ageing process].
journal, 2014