Livagen
also known as KEDA, Lys-Glu-Asp-Ala
Synthetic tetrapeptide (Lys-Glu-Asp-Ala) developed in the Khavinson bioregulator tradition for liver tissue support. Animal models demonstrate hepatoprotective effects in fibrosis, acute and chronic hepatitis, with tissue-specific stimulation of hepatocyte protein synthesis and age-dependent normalization of digestive enzyme activity. Resists hydrolysis by intestinal peptidases; oral administration viable.
At a glance
Oral or SQ · Tissue-specific to liver
Primary target — Hepatocyte protein synthesis machinery [brodski-2001].
Pathway — Tissue-specific bioregulator → Hepatocyte stimulation → Protein synthesis normalization [brodski-2001][khavinson-2001].
Downstream effect — Age-dependent enzyme normalization, hepatoprotection in fibrosis/hepatitis models, elevated protein synthesis in senescent hepatocytes.
Origin — Directed chemical synthesis from amino acid analysis of liver polypeptide preparations (Ventvil).
| Parameter | Value |
|---|---|
| Animal dose (oral) | Not specified in abstracts; 2-week administration protocol [timofeeva-2005]Per os administration in rats. |
| Duration (experimental) | 2 weeks (enzyme study); up to 24 months (cell culture) [timofeeva-2005][brodski-2001] |
| Route | Oral or subcutaneousResists peptidase hydrolysis, enabling oral bioavailability. [timofeeva-2005] |
| Evidence basis | Animal models (rats, 1–24 months age); in vitro hepatocyte culture [timofeeva-2005][brodski-2001][khavinson-2002] |
| Human data | None in provided literature |
Reconstitution
A pure mass-to-volume utility. Enter what you have in the vial; the atlas computes the volume per dose. No prescription information.
Evidence base: Russian-language clinical literature, primarily from the St. Petersburg Institute of Bioregulation and Gerontology (Khavinson school), 1985 onward. Not extensively peer-reviewed in Western journals.
- 01Route selection
Oral administration supported by peptidase resistance. Subcutaneous route used in organotypic culture experiments. [timofeeva-2005][khavinson-2001]
- 02Timing
No specific timing documented. Two-week protocols used in animal models with daily administration. [timofeeva-2005]
- 03Age-dependent response
Elderly individuals may exhibit different enzyme normalization patterns than younger cohorts, based on rat age-stratified findings. [timofeeva-2005]
Sources
of 32 rendered claims carry a resolvable citation.
- [brodski-2001]Brodskiĭ 2001 — [Rhythm of protein synthesis in cultures of hepatocytes from rats of different ages. Norm and effect of the peptide livagen].
journal, 2001 - [khavinson-2001]Khavinson 2001 — Tissue-specific effects of peptides.
journal, 2001 - [khavinson-2002]Khavinson 2002 — Effects of short peptides on thymocyte blast transformation and signal transduction along the sphingomyelin pathway.
journal, 2002 - [kuznik-2020]Kuznik 2020 — [The influence of polypeptide liver complex and tetrapeptide KEDA on organism physiological function in norm and age-related pathology.].
journal, 2020 - [timofeeva-2005]Timofeeva 2005 — [Effect of peptide Livagen on activity of digestive enzymes in gastrointestinal tract and non-digestive organs in rats of different ages].
journal, 2005