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Specimen Atlas of Research Peptides81 plates · MIT
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61Plate 61Reviewed 2026-04-27

PTD-DBM

Fusion Peptide

also known as Protein Transduction Domain-Dishevelled Binding Motif, PTD-fused Dvl-binding motif

Fusion peptide combining a protein transduction domain with a Dishevelled-binding motif. Inhibits CXXC5–Dishevelled interaction, activating Wnt/β-catenin signaling. Animal models demonstrate hair regeneration via PGD2-mediated pathway reversal and accelerated wound healing with reduced scar formation.

§ I

At a glance

Administration
Topical / SQ
[lee-2023][ryu-2023]
Evidence level
Animal-only
Primary pathway
Wnt/β-catenin
Route

Topical / SQ · Study-dependent

§ II

Mechanism

Edit ↗

Primary target — CXXC5–Dishevelled protein-protein interaction.

Pathway — Inhibit CXXC5 binding to Dishevelled → Release Wnt/β-catenin pathway inhibition [lee-2015][ryu-2023].

Downstream effect — Activated Wnt/β-catenin signaling promotes hair follicle regeneration, dermal stem cell activation, reduced myofibroblast differentiation.

Origin — Engineered fusion: cell-penetrating PTD sequence + Dvl-binding motif targeting CXXC5.

Feedback intact — Not applicable — pathway derepression rather than receptor agonism.

§ III

Dosage

Protocols described in the cited literature; not medical advice.

Edit ↗
ParameterValue
Wound healing protocolHydrogel patch delivery (concentration not disclosed)Pyrogallol-HA patch, murine model.
Hair regeneration protocolTopical application (exact dose not disclosed)Wound-induced hair neogenesis model, mice.
Evidence basisAnimal models only (mice)
Co-administrationValproic acid (GSK-3β inhibitor) for wound healing synergy [lee-2023]Combined treatment maximized scar reduction.
Human translationNo published human studies
§ III · b

Reconstitution

A pure mass-to-volume utility. Enter what you have in the vial; the atlas computes the volume per dose. No prescription information.

Inputs
mg
mL
mcg
The calculator does pure mass-to-volume math. It does not recommend a dose. Refer to PTD-DBM's cited literature for protocol specifics.
Volumetric outputFig. C — reconstitution math
Volume per dose
0.100mL
≈ 10.0 units on a U-100 insulin syringe
Concentration
2500
mcg per mL
Doses per vial
20
at this dose
§ V

Adverse events

Severities follow the FDA / CTCAE convention.

Edit ↗
Reported adverse eventsmild
None reported in animal studies
Wnt pathway activation risksmoderate
Theoretical risk of aberrant proliferation; Wnt dysregulation linked to tumorigenesis
Long-term safetymoderate
Unknown — no chronic dosing or human data
Delivery vehicle effectsmild
HA-PG hydrogel well-tolerated in mice; human translation pending
Absolute contraindications
  • — Active malignancy (Wnt pathway involvement in tumorigenesis)
  • — Pregnancy / lactation (no safety data)
Relative contraindications
  • — History of Wnt-driven tumors
  • — Skin lesions with uncertain malignant potential
§ VI

Administration

Edit ↗
  1. 01
    Wound Healing Protocol (Animal Model)

    Pyrogallol-functionalized hyaluronic acid (HA-PG) hydrogel patch loaded with PTD-DBM peptide, applied directly to wound bed. Adhesive hydrogel provides sustained release over multiple days. [lee-2023]

  2. 02
    Hair Regeneration Protocol (Animal Model)

    Topical application to scalp or wound site. Precise formulation not disclosed; studies used Cxxc5 knockout or direct peptide application in wound-induced hair neogenesis models. [ryu-2023]

  3. 03
    Combination Therapy

    PTD-DBM + valproic acid (GSK-3β inhibitor) in HA-PG patch showed synergistic effect on scar reduction and regenerative wound healing. VPA enhances Wnt pathway activation downstream. [lee-2023]

  4. 04
    Storage & Handling

    Not disclosed in available literature. Peptide stability and storage conditions not published.

Appendix

Sources

25%

of 40 rendered claims carry a resolvable citation.

  1. [lee-2015]
    Lee 2015 — The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance
    Cell Metab, 2015
    PubMed →
  2. [lee-2023]
    Lee 2023 — Adhesive Hydrogel Patch-Mediated Combination Drug Therapy Induces Regenerative Wound Healing through Reconstruction of Regenerative Microenvironment.
    journal, 2023
    PubMed →
  3. [ryu-2023]
    Ryu 2023 — CXXC5 Mediates DHT-Induced Androgenetic Alopecia via PGD(2).
    journal, 2023
    PubMed →
Plate composed 2026-04-27 · maturity human-reviewed · schema v1 · Contributors: peptidesdb-core · 30 fields uncited — open contributions
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