Thymalin
also known as Thymalinum, thymus extract Khavinson
Polypeptide complex isolated from calf thymus by the Khavinson group (Saint Petersburg Institute of Bioregulation and Gerontology). Used in Russia for decades to support immune function in elderly and post-treatment patients. Russian clinical trials report restoration of T-cell populations and reduced infection rates. Limited Western data.
- Class
- Polypeptide complex (thymus-derived)
- Evidence level
- Human mechanistic evidence
- Regulatory status
- Not FDA-approved (US) — research use only
At a glance
IM · Daily for 5–10 days · 1-2×/year
Primary target — T-cell precursors + thymus-axis maturation pathway [khavinson-2002-thymalin].
Pathway — Modulation of T-cell differentiation + thymic hormone restoration in age-involuted thymus [khavinson-2002-thymalin].
Downstream effect — Restored T-cell populations, improved immune surveillance, reduced infection rates in elderly [khavinson-2002-thymalin].
Origin — Polypeptide fraction isolated from calf thymus extract [khavinson-2002-thymalin].
| Parameter | Value |
|---|---|
| Standard dose | 5–10 mg / day IM × 5–10 days [khavinson-2002-thymalin] |
| Frequency | Once daily during cycle |
| Lower / starter dose | 2.5 mg / day |
| Evidence basis | Russian clinical + in vitro [khavinson-2002-thymalin] |
| Duration | 5–10 day cycles, 1–2× per year |
| Reconstitution | Saline or bacteriostatic water |
| Timing | Morning preferred |
| Half-life | Hours (estimated) |
Reconstitution
A pure mass-to-volume utility. Enter what you have in the vial; the atlas computes the volume per dose. No prescription information.
- — Pregnancy / breastfeeding
- — Bovine protein hypersensitivity
- — Active autoimmune disease
- — Concurrent immunosuppressant therapy
- 01Reconstitution
Add 1–2 mL saline or bacteriostatic water per 10 mg vial.
- 02Injection site
Intramuscular — deltoid or gluteal. Rotate sites.
- 03Timing
Morning preferred during cycle.
- 04Storage
Lyophilised: refrigerate, light-protected. Reconstituted: use immediately.
- 05Needle
23–25G, 25–38 mm IM needle.
Frequently asked
How does Thymalin work?
Thymalin acts on T-cell precursors + thymus-axis maturation pathway, signalling via Modulation of T-cell differentiation + thymic hormone restoration in age-involuted thymus. [khavinson-2002-thymalin][khavinson-2002-thymalin]
Is Thymalin FDA-approved?
Thymalin is not FDA-approved in the United States and is handled as a research compound (research use only). Regulatory status may differ in other jurisdictions.
Sources
of 40 rendered claims carry a resolvable citation.
- [camerini-2001-talpha1]Camerini 2001 — Thymosin alpha-1: a clinical update
Curr Opin Investig Drugs, 2001
Thymosin α-1 immune modulation review. - [khavinson-2002-thymalin]Khavinson 2002 — Peptides and Ageing
Neuroendocrinol Lett, 2002
Thymalin foundational immune-modulator review by Khavinson group.