C10H11N2+ · 159.21 g/mol · PubChem CID 950107 ↗
5-Amino-1MQ
also known as 5-Amino-1-Methylquinolinium, 5A-1MQ
Selective small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme overexpressed in obesity that consumes SAM while methylating nicotinamide, indirectly lowering NAD+ salvage. Inhibition has been reported to raise cellular SAM and NAD+. Listed for class completeness; not a peptide. Animal studies (Neelakantan 2018) showed reversal of high-fat-diet-induced obesity in mice. [neelakantan-2018-namq]
- Class
- NNMT Inhibitor (small molecule)
- Evidence level
- Strong animal evidence
- Regulatory status
- Not FDA-approved (US) — research use only
At a glance
Oral · Once daily fasted
Primary target — Nicotinamide N-methyltransferase (NNMT) [neelakantan-2018-namq].
Pathway — NNMT inhibition → preserved cellular SAM + NAD⁺ → restored methylation balance + ↑ thermogenic gene expression [neelakantan-2018-namq].
Downstream effect — Reversal of HFD-induced obesity in murine models; improved metabolic profile [neelakantan-2018-namq].
Origin — Selective small-molecule inhibitor designed in academic medicinal chemistry programs [neelakantan-2018-namq].
| Parameter | Value |
|---|---|
| Standard dose | 100–200 mg / day oral [neelakantan-2018-namq]Anecdotal community range; murine doses scaled. |
| Frequency | Once daily, fasted |
| Lower / starter dose | 50 mg / day |
| Evidence basis | Animal-strong; no human RCT data [neelakantan-2018-namq] |
| Duration | 8–12 weeks per cycle |
| Form | Oral capsule |
| Timing | Morning fasted preferred |
| Half-life | Hours (estimated; no human PK published) |
Reconstitution
A pure mass-to-volume utility. Enter what you have in the vial; the atlas computes the volume per dose. No prescription information.
- — Pregnancy / breastfeeding
- — Active malignancy
- — Methylation-sensitive conditions (MTHFR mutation)
- — Concurrent niacin / NAD+ precursor supplementation (theoretical interference)
- 01Form
Oral capsule. No injection.
- 02Administration
Take with water, fasted preferred.
- 03Timing
Morning fasted.
- 04Storage
Room temp ≤25 °C, dry place.
- 05Caveat
Monitor B-vitamin status with chronic use.
Frequently asked
How does 5-Amino-1MQ work?
5-Amino-1MQ acts on Nicotinamide N-methyltransferase (NNMT), signalling via NNMT inhibition → preserved cellular SAM + NAD⁺ → restored methylation balance + ↑ thermogenic gene expression. [neelakantan-2018-namq][neelakantan-2018-namq]
Is 5-Amino-1MQ FDA-approved?
5-Amino-1MQ is not FDA-approved in the United States and is handled as a research compound (research use only). Regulatory status may differ in other jurisdictions.
Sources
of 38 rendered claims carry a resolvable citation.
- [neelakantan-2018-namq]Neelakantan 2018 — Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice
Biochem Pharmacol, 2018
5-Amino-1MQ (NNMT inhibitor) reverses HFD obesity in mice.