Adamax
also known as ACTH(4-10) analog, corticotropin 4-10 derivative
Synthetic ACTH(4-10) analogue developed in Russia, structurally related to Semax but with distinct amino acid modifications at positions 8-10. Investigated primarily in Russian-language literature for cognitive enhancement, neuroprotection, and BDNF upregulation. Animal studies demonstrate modulation of hippocampal BDNF/trkB signaling, normalization of circadian rhythms, and attenuation of stress-related behavioral alterations. Limited human data exists; most evidence derives from rodent models.
At a glance
Intranasal · Research Use Only
Primary target — Melanocortin receptors (MC-Rs) in hippocampus and cortex.
Pathway — ACTH(4-10) fragment → MC-R binding → BDNF/trkB upregulation → neurotrophic signaling.
Downstream effect — Increased hippocampal BDNF expression, trkB tyrosine phosphorylation, enhanced conditioned avoidance learning, circadian rhythm normalization [dolotov-2006][arushanian-2008].
Origin — ACTH(4-10) fragment with modified amino acid sequence at positions 8, 9, 10 [teter-2001].
Feedback intact — Non-endocrine — devoid of adrenal axis effects [van-1978].
| Parameter | Value |
|---|---|
| Animal dose (rat) | 50 mcg/kg body weight [dolotov-2006]Single intranasal application; produced maximal BDNF response. |
| Route | Intranasal [dolotov-2006][smolnik-2000] |
| Frequency | Single-dose or chronic administration protocolsChronic dosing normalized circadian rhythms; single-dose produced acute BDNF elevation. |
| Human dose (exploratory) | Not established — limited human dataACTH(4-10) and analogs dosed 30–60 mcg intranasally in early human studies. |
| Evidence basis | Animal (rodent, rabbit) studies; minimal human RCT data |
| Timing | Variable — chronic administration for circadian effects |
Reconstitution
A pure mass-to-volume utility. Enter what you have in the vial; the atlas computes the volume per dose. No prescription information.
- — Pregnancy and lactation (precautionary; no data)
- — Active cardiovascular instability (due to potential pressor effects)
- — Hypertension (monitor BP if using higher doses)
- — Renal impairment (natriuretic effects may alter electrolyte balance)
- 01Reconstitution (if lyophilised)
Add sterile water or bacteriostatic water to lyophilised vial per manufacturer guidance. Roll gently — do not shake. Ensure clarity before use.
- 02Route
Intranasal administration is the primary route in animal and exploratory human studies. Delivered via nasal spray or dropper to ensure mucosal absorption. [dolotov-2006][smolnik-2000]
- 03Timing
Variable. Single-dose protocols for acute cognitive tasks; chronic daily dosing for circadian rhythm normalization and sustained neuroprotection.
- 04Storage
Lyophilised: room temperature, light-protected. Reconstituted: refrigerate 2–8 °C, use within manufacturer-specified timeframe.
Sources
of 47 rendered claims carry a resolvable citation.
- [arushanian-2008]Arushanian 2008 — [Chronotropic activity of semax].
journal, 2008 - [dolotov-2006]Dolotov 2006 — Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus.
journal, 2006 - [glazova-2021]Glazova 2021 — Semax, synthetic ACTH(4-10) analogue, attenuates behavioural and neurochemical alterations following early-life fluvoxamine exposure in white rats.
journal, 2021 - [gruber-1984]Gruber 1984 — Natriuretic and hypertensive activities reside in a fragment of ACTH.
journal, 1984 - [smolnik-2000]Smolnik 2000 — Event-related brain potentials and working memory function in healthy humans after single-dose and prolonged intranasal administration of adrenocorticotropin 4-10 and desacetyl-alpha-melanocyte stimulating hormone.
journal, 2000 - [teter-2001]Teter 2001 — Changes in rabbits' behaviour under the influence of corticotropin derivative analogue 4-10 in spontaneous conditions.
journal, 2001 - [van-1978]van 1978 — [Possible consequence of ACTH-like peptides for human mental performance (author's transl)].
journal, 1978