Cortagen
also known as Ala-Glu-Asp-Pro, AEDP
Synthetic tetrapeptide (Ala-Glu-Asp-Pro) derived from brain cortex peptide analysis in the Khavinson bioregulator tradition. Animal models demonstrate antioxidant activity, reduction of lipid peroxidation products and oxidative protein modification in rat serum and cerebral cortex. Distinguished from epithalon by terminal proline substitution; shows divergent biological activity profile in avian hypophysectomy models.
At a glance
Injectable · Animal models
Primary target — Cerebral cortex tissue — molecular targets under investigation.
Pathway — Antioxidant pathway modulation — suppression of LPO cascade, reduction of protein oxidative modification [kozina-2007].
Downstream effect — Decreased lipid peroxidation products, reduced oxidative protein damage, altered gene expression in cardiac tissue [kozina-2007][anisimov-2004].
Origin — Synthetic tetrapeptide derived from amino acid analysis of natural brain cortex peptide preparation Cortexin [anisimov-2004].
| Parameter | Value |
|---|---|
| Animal model dose (rat) | Injection protocol (dose not specified in abstracts)Multiple injections over study period. |
| Avian model dose (chicken) | 40-day injection course [kuznik-2008]Compared to epithalon in hypophysectomized and aged birds. |
| Human peripheral nerve study | Therapeutic course (protocol details not provided)Posttraumatic recovery context — reference cited but not detailed. |
| Evidence basis | Animal mechanistic studies |
| Route | Injectable (inferred from animal protocols) |
Reconstitution
A pure mass-to-volume utility. Enter what you have in the vial; the atlas computes the volume per dose. No prescription information.
Evidence base: Russian-language clinical literature, primarily from the St. Petersburg Institute of Bioregulation and Gerontology (Khavinson school), 1985 onward. Not extensively peer-reviewed in Western journals.
- 01Preparation
Reconstitute lyophilised peptide with bacteriostatic water per supplier protocol. Exact volumes depend on concentration supplied.
- 02Injection site
Subcutaneous injection typical for bioregulatory peptides — abdomen or thigh. Rotate sites.
- 03Timing
Animal protocols used repeated dosing over weeks. Human timing not established — evening administration common in Khavinson tradition.
- 04Storage
Lyophilised: refrigerate or freeze per supplier. Reconstituted: refrigerate 2–8 °C, use within guideline window.
Sources
of 35 rendered claims carry a resolvable citation.
- [anisimov-2004]Anisimov 2004 — Elucidation of the effect of brain cortex tetrapeptide Cortagen on gene expression in mouse heart by microarray.
journal, 2004 - [kozina-2007]Kozina 2007 — Effects of bioactive tetrapeptides on free-radical processes.
journal, 2007 - [kuznik-2008]Kuznik 2008 — [Effects of epithalon and cortagene on immunity and hemostasis in neonatally hypophysectomized chicken and old birds].
journal, 2008