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Specimen Atlas of Research Peptides30 plates · MIT
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XVIIPlate XVIIReviewed 2026-04-25

Pinealon

Tetrapeptide bioregulator

also known as Glu-Asp-Arg, EDR

Synthetic tetrapeptide (Glu-Asp-Arg) developed at the Saint Petersburg Institute of Bioregulation and Gerontology. Russian literature reports neuroprotective and antioxidant effects, particularly in age-related cognitive decline. Limited Western RCT data. Frequently used anecdotally for cognitive support and longevity, often in combination with Epitalon.

§ I

At a glance

Per cycle dose
5–10 mg
[khavinson-2014-pinealon]
Mechanistic
Human
[khavinson-2014-pinealon]
Half-life (est)
Hours
Route

SQ or IM · Daily for 10 days · 1-2×/year

§ II

Mechanism

Primary target — Antioxidant defense + neuronal gene expression (proposed) [khavinson-2014-pinealon].

Pathway — Modulation of antioxidant enzymes (SOD, catalase) + neurotrophic factor expression [khavinson-2014-pinealon].

Downstream effect — Reduced oxidative stress in neurons; improved cognitive function in age-related decline [khavinson-2014-pinealon].

Origin — Synthetic 4-AA peptide derived from pineal gland extract [khavinson-2014-pinealon].

§ III

Dosage

Protocols described in the cited literature; not medical advice.

ParameterValue
Standard dose5–10 mg / day for 10 days [khavinson-2014-pinealon]
FrequencyOnce daily during cycle
Lower / starter dose2.5 mg / day
Evidence basisRussian clinical trials + in vitro [khavinson-2014-pinealon]
Duration10-day cycles, 1–2× per year
ReconstitutionBacteriostatic water
TimingNo specific time
Half-lifeHours
§ III · b

Reconstitution

A pure mass-to-volume utility. Enter what you have in the vial; the atlas computes the volume per dose. No prescription information.

Inputs
The calculator does pure mass-to-volume math. It does not recommend a dose. Refer to Pinealon's cited literature for protocol specifics.
Volumetric outputFig. C — reconstitution math
Volume per dose
0.050mL
≈ 5.0 units on a U-100 insulin syringe
Concentration
5000
mcg per mL
Doses per vial
40
at this dose
§ V

Adverse events

Severities follow the FDA / CTCAE convention.

Injection site reactionmild
Mild irritation
Long-term safetymoderate
Limited Western data
Pregnancy / OBsevere
Avoid
Absolute contraindications
  • — Pregnancy / breastfeeding
Relative contraindications
  • — Active malignancy (theoretical via gene expression modulation)
§ VI

Administration

  1. 01
    Reconstitution

    Add 1–2 mL bacteriostatic water to 10 mg vial.

  2. 02
    Injection site

    SQ — abdomen preferred.

  3. 03
    Timing

    Daily during cycle, any time.

  4. 04
    Storage

    Lyophilised: room temp. Reconstituted: refrigerate ≤30 days.

  5. 05
    Needle

    29–31G, 4–8 mm insulin syringe.

§ VII

Synergies

moderate synergy
+
Pinealon + Epitalon

Pinealon (neuroprotection) + Epitalon (telomerase activation) form the canonical Khavinson "longevity stack" — both pineal-derived bioregulators with complementary axes. Pinealon supports neuronal antioxidant defense; Epitalon supports telomere maintenance. Anecdotally cycled together 1–2× per year.

Primary benefit — Neuroprotection + telomere preservation
Appendix

Sources

33%

of 36 rendered claims carry a resolvable citation.

  1. [khavinson-2003]
    Khavinson 2003 — Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells
    Bull Exp Biol Med, 2003
    PubMed →
  2. [khavinson-2014-pinealon]
    Khavinson 2014 — Tetrapeptide pinealon: neuroprotective and antioxidant effects
    Bull Exp Biol Med, 2014
    Source →
Plate composed 2026-04-25 · maturity draft · schema v1 · Contributors: peptidesdb-core · 24 fields uncited — open contributions
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