C15H26N6O8 · 418.4 g/mol · PubChem CID 10273502 ↗
Pinealon
also known as Glu-Asp-Arg, EDR
Synthetic tetrapeptide (Glu-Asp-Arg) developed at the Saint Petersburg Institute of Bioregulation and Gerontology. Russian literature reports neuroprotective and antioxidant effects, particularly in age-related cognitive decline. Limited Western RCT data. Frequently used anecdotally for cognitive support and longevity, often in combination with Epitalon.
- Class
- Tetrapeptide bioregulator
- Evidence level
- Human mechanistic evidence
- Regulatory status
- Not FDA-approved (US) — research use only
At a glance
SQ or IM · Daily for 10 days · 1-2×/year
Primary target — Antioxidant defense + neuronal gene expression (proposed) [khavinson-2014-pinealon].
Pathway — Modulation of antioxidant enzymes (SOD, catalase) + neurotrophic factor expression [khavinson-2014-pinealon].
Downstream effect — Reduced oxidative stress in neurons; improved cognitive function in age-related decline [khavinson-2014-pinealon].
Origin — Synthetic 4-AA peptide derived from pineal gland extract [khavinson-2014-pinealon].
| Parameter | Value |
|---|---|
| Standard dose | 5–10 mg / day for 10 days [khavinson-2014-pinealon] |
| Frequency | Once daily during cycle |
| Lower / starter dose | 2.5 mg / day |
| Evidence basis | Russian clinical trials + in vitro [khavinson-2014-pinealon] |
| Duration | 10-day cycles, 1–2× per year |
| Reconstitution | Bacteriostatic water |
| Timing | No specific time |
| Half-life | Hours |
Reconstitution
A pure mass-to-volume utility. Enter what you have in the vial; the atlas computes the volume per dose. No prescription information.
- — Pregnancy / breastfeeding
- — Active malignancy (theoretical via gene expression modulation)
- 01Reconstitution
Add 1–2 mL bacteriostatic water to 10 mg vial.
- 02Injection site
SQ — abdomen preferred.
- 03Timing
Daily during cycle, any time.
- 04Storage
Lyophilised: room temp. Reconstituted: refrigerate ≤30 days.
- 05Needle
29–31G, 4–8 mm insulin syringe.
Frequently asked
How does Pinealon work?
Pinealon acts on Antioxidant defense + neuronal gene expression (proposed), signalling via Modulation of antioxidant enzymes (SOD, catalase) + neurotrophic factor expression. [khavinson-2014-pinealon][khavinson-2014-pinealon]
Is Pinealon FDA-approved?
Pinealon is not FDA-approved in the United States and is handled as a research compound (research use only). Regulatory status may differ in other jurisdictions.
Sources
of 36 rendered claims carry a resolvable citation.
- [khavinson-2014-pinealon]Khavinson 2014 — Tetrapeptide pinealon: neuroprotective and antioxidant effects
Bull Exp Biol Med, 2014
Pinealon (Glu-Asp-Arg) Russian peptide bioregulator — neuroprotection.